Herbs, held to a higher standard.

Every ingredient in Soultrum earns its place: a real mechanism, a real research story, and a dose chosen on purpose. This page walks through all of it, one ingredient at a time.

Doctor formulatedStandardized extractsThird-party testedcGMP facility, made in the USA

One honest note before we begin: the research described here is ingredient science, the published study record behind each botanical and nutrient. It is the reason each one is in the bottle, told without inflation.

Three rules, no exceptions.

Dr. Edward Ehsan formulated Soultrum around principles that show up on the label, not just the marketing.

Standardized where it counts

The anchor botanicals are standardized extracts, like KSM-66 Ashwagandha, so every capsule carries the same concentration the research used, not whatever the harvest happened to yield.

Honest doses

A deliberate 3mg of melatonin instead of a mega-dose. Full label transparency on every vitamin and mineral. Enough to matter, never enough to bulldoze your own biology.

Tested, then tested again

Both formulas are made in a cGMP-certified US facility and every batch is third-party tested for purity and potency. Vegan capsules, non-GMO, gluten-tested.

Meet the two doctors behind the label

The whole system runs on a 24-hour clock.

Cortisol is built to peak in the morning and fade by night, while melatonin does the opposite. Stress bends that rhythm out of shape: wired days, restless nights, and each one feeding the other.

That is why Soultrum is a system rather than a pill. The daily formula supports a steady daytime arc, the PM formula supports the nighttime handoff, and the two together work on the cycle from both ends.†

Soultrum Duo The stress and sleep cycle

Illustrative of how the Duo is designed to support your full 24 hours, not a clinical measurement.

By day: the Soultrum blend, ingredient by ingredient.

Seven botanicals, amino acids and a probiotic share the 824.67 mg daily blend. Here is what each one is actually doing.

Dried ashwagandha roots on washed linen in soft window light

KSM-66 Ashwagandha

Withania somnifera

The root of Withania somnifera, as KSM-66 organic root extract by day and whole root powder at night.

Soultrum · Part of the 824.67 mg daily botanical blendSoultrum PM · 300 mg per serving

How it works. Ashwagandha is the textbook adaptogen. Central to that story is cortisol, the hormone your body releases under pressure, useful in short bursts and best kept in a healthy rhythm. Research on the root has focused on how it supports that rhythm, which is why its effect is often described as a lower idle rather than a switch turning off.†

What the research looks at. KSM-66 is among the most widely studied ashwagandha root extracts available. Randomized, placebo controlled trials have studied its effects on perceived everyday stress, cortisol, and sleep quality. That breadth is why ashwagandha earns a place in both Soultrum formulas, as a concentrated extract by day and as gentler whole root powder at night.

Where it comes from. Ashwagandha has long been a cornerstone of Ayurveda, India’s traditional system of herbal practice, with a written record that runs back roughly two thousand years. It was classically taken as a tonic for strength and vitality, and its Sanskrit name translates roughly to smell of the horse, a nod to the robust energy it was thought to impart.

In the formula. By day it sets the steady baseline that rhodiola builds on, and by night it works alongside L-Theanine and chamomile to ease the handoff from a full mind to an unwinding one.

Steady, not sedated. Taken consistently, it may help hard days feel more workable and the wind down at night come a little easier.†

Chunks of dried rhodiola root with golden brown bark

Rhodiola Root Extract

Rhodiola rosea

A root extract from Rhodiola rosea, a hardy plant of Arctic coasts and high mountain regions.

Soultrum · Part of the 824.67 mg daily botanical blend

How it works. Rhodiola is the other kind of adaptogen. Where ashwagandha leans calm, rhodiola leans stamina: it is studied for how the mind keeps its footing when demand is high and energy wants to fade. Research has explored how compounds in the root interact with the systems that manage the stress response and the sense of mental fatigue that follows a long push.†

What the research looks at. Researchers have been testing rhodiola on tired, overworked people for decades. Placebo controlled trials have studied its effects on occasional stress, occasional fatigue, and mental performance during demanding stretches of work, from single doses before a hard task to consistent daily use over time.

Where it comes from. Rhodiola grows where almost nothing else will, in the thin soil of Arctic coasts and high mountain ranges across Europe and Asia. People in Scandinavia, Siberia, and other cold northern regions traditionally used the golden root to help endure long winters, hard physical work, and life at altitude.

In the formula. It is the counterweight to ashwagandha in the daily blend: ashwagandha settles the baseline while rhodiola supports the push, so the formula covers calm and drive at the same time.

Present, not amped. On long afternoons it may be easier to stay with the task in front of you, with less of that running on fumes feeling a stressful stretch usually brings.†

Deep red saffron threads spilling from a small ceramic dish

Saffron Stigmas Extract

Crocus sativus

An extract of the dried crimson stigmas of Crocus sativus, the saffron crocus, gathered by hand at bloom.

Soultrum · Part of the 824.67 mg daily botanical blend

How it works. The compounds that give saffron its deep color and distinctive aroma appear to be the same ones that matter for mood. Research suggests they support healthy activity of serotonin, one of the brain’s main mood messengers, and help support a balanced response to everyday stress. In plain terms, saffron seems to help the system that steadies you do its job.†

What the research looks at. Modern mood research keeps returning to saffron. Placebo controlled trials have followed adults through weeks of consistent daily use, watching everyday mood and emotional wellbeing rather than any single dramatic effect. For a kitchen spice, its research footprint runs unusually deep.

Where it comes from. Each saffron crocus opens for only a brief window and gives just three stigmas, still picked by hand the way harvesters across Persia and the Mediterranean have done for thousands of years. That patient labor made saffron among the most treasured spices on earth, valued in those cultures at the table and, traditionally, for brightening the spirit.

In the formula. Saffron shares the daily blend with 5-HTP: 5-HTP supplies raw material for serotonin while saffron supports how your brain puts that messenger to work.

It tends to read as ordinary days sitting a little easier, a baseline that holds rather than a mood that spikes.†

Dried griffonia seeds beside a small wooden scoop

5-HTP (Griffonia)

Griffonia simplicifolia

A naturally occurring amino acid drawn from the seeds of Griffonia simplicifolia, a West African climbing shrub.

Soultrum · Part of the 824.67 mg daily botanical blend

How it works. Your body builds serotonin, a chemical messenger that helps regulate mood, through a short series of steps that begins with protein from your food. 5-HTP is the last stop on that path before serotonin itself. Taking it directly supports the final conversion, and unlike serotonin, 5-HTP can pass from the bloodstream into the brain, so it arrives where the work happens.†

What the research looks at. The pathway itself is settled biochemistry: 5-HTP is the direct precursor to serotonin, the raw material your body converts in a single step, and that conversion is described in standard physiology. Beyond the pathway, randomized, placebo controlled trials have studied supplemental 5-HTP in adults, and research continues to explore its role in everyday mood support.

Where it comes from. Griffonia simplicifolia is a woody climbing shrub native to West and Central Africa. Its glossy black seeds turned out to be one of nature’s only rich sources of 5-HTP, which is why supplemental 5-HTP comes from this one plant rather than a lab.

In the formula. 5-HTP leans on the Vitamin B6 in the same formula, because your body uses B6 as a helper molecule in the very step that turns 5-HTP into serotonin.

Quiet work. You are more likely to notice it as evenness across the day than as any single moment you can point to.†

Loose dried green tea leaves with fresh camellia leaves

L-Theanine

Camellia sinensis

An amino acid found almost exclusively in tea leaves, the calming half of a cup of green tea.

Soultrum · Part of the 824.67 mg daily botanical blendSoultrum PM · 200 mg

How it works. L-theanine crosses into your brain, where it is associated with alpha waves, the gentle electrical rhythm your brain produces when you are relaxed but still fully awake. It is the pattern of quiet, absorbed moments, a few minutes into a walk or deep in a good book. Rather than sedating you, l-theanine supports that settled, alert state so your attention has somewhere calm to rest.†

What the research looks at. Trials have explored l-theanine’s effects on measures of relaxation, attention, and sleep quality, both on its own and alongside caffeine. Studies using brain wave recordings have also observed the relaxed rhythm it is best known for.

Where it comes from. People have been drinking green tea for its calm, clear energy for well over a thousand years, from Chinese tea culture to the Japanese matcha ceremony. L-theanine is a large part of why a cup of tea settles you in a way coffee never quite does.

In the formula. In the daily formula it balances the energizing edge of rhodiola, and in the PM formula it settles mental chatter so melatonin’s sleep signal can land.

The mental noise turns down while the lights stay on. Calm, not sleepy.†

Fresh turmeric fingers, one snapped open to show the orange interior

Turmeric Root Extract

Curcuma longa

A concentrated extract of the golden Curcuma longa root, the same spice that colors curry.

Soultrum · Part of the 824.67 mg daily botanical blend

How it works. Turmeric’s most studied compounds are curcuminoids, the golden pigments that give the root its color. They act as antioxidants, sweeping up the unstable molecules that build up through normal metabolism and everyday stress. That quiet cellular housekeeping is why turmeric is framed as whole body support rather than a single pathway ingredient.†

What the research looks at. Thousands of published studies later, curcumin remains one of the most examined plant compounds in science. Trials have looked at its antioxidant activity along with its role in supporting joint comfort, a healthy inflammatory response, and mood.

Where it comes from. In India, turmeric never left the kitchen. It has gone into food, tonics, and golden milk for thousands of years, medicine and meal in the same spoonful, and a warm cup of golden milk before bed is still an ordinary evening in millions of households.

In the formula. It shares the daily blend with Saffron Stigmas Extract, a second golden botanical studied for mood, so foundational antioxidant support and direct mood support travel together.

Turmeric is a background player, and that is the point. You will not feel it hour to hour, but it supports the whole body foundation that a steady mood is built on.†

Soultrum clear capsules filled with herbal powder, one pulled open

Bacillus coagulans Complex

Bacillus coagulans

A hardy probiotic bacterium that travels in a protective spore, delivered as a stabilized complex in the daily blend.

Soultrum · Part of the 824.67 mg daily botanical blend

How it works. Many probiotics struggle to survive the trip through stomach acid. Bacillus coagulans travels sealed inside a tough natural shell called a spore, which lets it pass through intact and wake up in the friendlier territory of your intestines, where it supports a balanced gut community. That community matters for mood because your gut and brain talk constantly through nerves and chemical signals.†

What the research looks at. Spore forming probiotics are an active corner of modern research. Randomized trials have examined Bacillus coagulans for its role in supporting digestive comfort and a balanced gut environment, and research continues to explore how the gut brain connection shapes mood and the everyday stress response.

Where it comes from. Bacillus coagulans was first identified in the early twentieth century, isolated from coagulated milk, which is how it earned its name. It has since become one of the most widely used spore forming probiotics in foods and supplements around the world.

In the formula. It backs up 5-HTP in the daily formula, helping keep the gut environment friendly while 5-HTP supplies the raw material your body uses to make serotonin, most of which is produced in the gut.

You may notice digestion that feels settled and predictable, a quieter middle that lets the rest of your day follow suit.†

The support stack.

Five nutrients sit under the botanicals: the minerals and B vitamins the formulas lean on to do their work. Doses straight from the label.

Magnesium Glycinate

Soultrum · 100 mg (24% DV)Soultrum PM · 11 mg (3% DV)

Magnesium is a workhorse. Your body leans on it for hundreds of enzyme reactions, many of them in nerves and muscle, where it works as a cofactor, a helper molecule enzymes need before they can act. In muscle fibers and nerve cells it counterbalances calcium, which is why healthy magnesium status supports release and relaxation instead of tension. Binding each magnesium to glycine helps the mineral absorb well and stay gentle on your stomach. That is why the glycinate form is here.†

Worth knowing. Start with a plain fact: nutrition research has long observed that many adults fall short of recommended magnesium intakes from food alone. Placebo controlled trials have explored magnesium’s role in supporting relaxation, sleep quality, and a healthy stress response, and absorption comparisons between forms are part of why chelated forms such as glycinate are often chosen.

Vitamin D (Cholecalciferol)

Soultrum · 25 mcg (125% DV)

Vitamin D behaves less like a typical vitamin and more like a signaling hormone. After your liver and kidneys activate it, it docks with vitamin D receptors, tiny landing sites found in tissues all over the body, including the brain and immune cells, where it helps switch specific genes on and off. That reach is the point: one nutrient, quietly supporting bone strength, immune defenses, and a settled mood at once.†

Worth knowing. Researchers have tracked vitamin D’s relationship to mood, immune function, and overall wellness for decades, and placebo controlled trials have studied supplementation across many populations. One thing is not in dispute: your skin needs direct sunlight to make vitamin D, and most modern life happens indoors, which is why the daily formula carries a full day’s worth and a little more.

Vitamin B6

Soultrum · 2 mg (118% DV)Soultrum PM · 5 mg (294% DV)

B6 is a cofactor: certain enzymes cannot finish their work without it. The enzymes that build serotonin and GABA both depend on it, which is why it sits alongside 5-HTP in the daily formula. The story continues after dark, because melatonin is made from serotonin, so the same quiet helper supports the supply line your body draws on at night.†

Worth knowing. The chemistry here is not speculative. B6’s role in neurotransmitter production, the assembly of the brain’s chemical messengers, is settled textbook biochemistry that has been described in detail for decades. Beyond those fundamentals, research has also explored how B6 status relates to mood and healthy sleep in adults.

Folate

Soultrum · 333 mcg DFE (83% DV)

Folate is a courier. It hands off tiny chemical fragments that your cells spend on two big jobs: building fresh DNA every time the body makes a new cell, and keeping the methylation cycle turning, a recycling loop that helps supply raw materials for your everyday mood chemistry. When that loop runs well, everything downstream has what it needs.†

Worth knowing. Folate’s role in cell division and the methylation cycle is foundational biochemistry rather than an open question. Research has also explored the relationship between folate status and mood in adults. The science here is old, deep, and still growing.

Vitamin B12 (Methylcobalamin)

Soultrum · 100 mcg (4,167% DV)

B12 sits at the center of methylation, a constant chemical handoff your cells use to build the messenger molecules your brain runs on, maintain the insulation around nerve fibers, and turn the food you eat into usable energy. Many supplements use a form your body must first convert; methylcobalamin arrives already carrying the methyl group the work requires. Same vitamin, less processing between the capsule and the cell.†

Worth knowing. The core biology here is settled science: B12 is essential for red blood cell formation, nervous system function, and the energy metabolism of every cell you have. Research has also explored how B12 status relates to mood and mental energy, especially when dietary intake runs low. The label number looks big because B12 is absorbed inefficiently and is water soluble, so a generous dose helps enough get through, and your body clears what it does not use.

By night: built around one gentle signal.

3mg

on purpose.

Melatonin

A supplemental form of the darkness hormone your own pineal gland releases each night.

How it works. As evening light fades, a small gland deep in your brain releases melatonin into the bloodstream, and rising levels tell receptors throughout the body that night has arrived. That nightly rise anchors your circadian rhythm, the internal clock that decides when you drift down and when you surface. Soultrum PM supplies a deliberate 3 mg, a clear cue designed to work with your body’s own signal rather than replace it.†

What the research looks at. Melatonin is one of the most widely studied ingredients in the entire sleep category. Randomized, placebo controlled trials have explored its role in supporting sleep onset and healthy sleep wake timing, and its function as the body’s own darkness signal is well established science. Research has also looked closely at timing and dose, which is part of why we kept this one low and precise.

In the formula. It pairs naturally with L-Theanine in Soultrum PM, melatonin cueing the body toward night while L-Theanine helps quiet a busy mind so the cue gets heard.

A cue, not a knockout. Very large doses of melatonin can leave some people foggy the next morning, so this formula keeps the dose low and lets your own biology do the rest, with the aim of waking up clear.†

Loose dried chamomile blossoms gathered on linen

Chamomile Flower Extract

Matricaria chamomilla

A concentrated extract of Matricaria chamomilla flowers, the small daisy family bloom behind Europe’s favorite bedtime tea.

Soultrum PM · 200 mg

How it works. Chamomile’s best studied constituent is apigenin, a natural compound concentrated in the flower heads. Apigenin binds gently to calming receptors in the brain, part of the nervous system’s built in braking system, and that gentle binding is thought to encourage the shift from alert to at ease. The effect is settling rather than sedating, which is why chamomile has always read as mild.†

What the research looks at. Chamomile is among the most widely consumed herbal preparations in the world, which has made it a natural subject for modern research. Placebo controlled trials have looked at chamomile extract for its role in supporting relaxation and restful sleep, and the way apigenin interacts with the brain’s calming receptors is well described science.

Where it comes from. Chamomile may be the most familiar calming plant on earth, brewed as an evening tea across Europe for many centuries and part of traditional herbal practice since antiquity. Grandmothers were pouring it long before anyone could explain why it worked.

In the formula. In Soultrum PM it is layered with passionflower and valerian, three botanicals from the same European evening tradition, so the wind down feels gradual instead of abrupt.

It feels like the capsule version of the tea, a soft easing at the edges of the evening.†

Dried valerian root strands in a small stoneware bowl

Valerian Root Powder

Valeriana officinalis

The dried, milled root of Valeriana officinalis, a flowering perennial that grows across Europe and Asia.

Soultrum PM · 200 mg

How it works. Valerian works with GABA, the chemical messenger your brain uses to quiet its own activity. Compounds in the root appear to support GABA’s calming signal at the junctions between nerve cells, helping a busy evening brain downshift toward rest. That mechanism supports settled, continuous rest across the whole night, which is why valerian is described in terms of steady sleep rather than a hard push into it.†

What the research looks at. Few sleep herbs have been studied as often as valerian. Randomized, placebo controlled trials have examined its effects on sleep quality and how settled people feel through the night, and research has explored how compounds in the root interact with the same GABA activity described above.

Where it comes from. Valerian appears in the writings of ancient Greek and Roman physicians, who valued the root as a calming herb for the night. It has held that same quiet job in European herbal practice for close to two thousand years.

In the formula. It picks up where melatonin leaves off: melatonin handles the timing signal that starts sleep, while valerian supports the settled calm of a restful night.

You know the difference between falling asleep and staying asleep. Valerian is in the PM formula to support the second: nights that feel continuous.†

A single fresh passionflower bloom with purple and white filaments

Passionflower Extract

Passiflora incarnata

An extract from the flowering vine Passiflora incarnata, native to the Americas.

Soultrum PM · 150 mg

How it works. Compounds in passionflower appear to support the activity of GABA, the brain’s own hush signal. When that calming signal has support, looping thoughts get less traction, and the mental chatter that shows up right at lights out has less to hold onto. It encourages quiet rather than flipping a switch.†

What the research looks at. Researchers interested in calm and sleep quality have studied passionflower, including in randomized, placebo controlled trials. Work has also explored the interaction between its compounds and GABA activity, and its long record in two herbal traditions is part of why it keeps drawing that attention.

Where it comes from. Native peoples of the Americas used passionflower as a calming herb long before European contact. Spanish travelers later carried it across the Atlantic, and it became a fixture of European herbalism for restless evenings.

In the formula. It runs beside L-Theanine, which encourages the relaxed alpha wave state while passionflower supports the GABA activity that quiets the chatter underneath it.

The lights are off and your mind is still walking through tomorrow. Passionflower is in the PM formula to support quiet in that exact moment, a wind down that feels calm, not blank.†

Also on the night shift

L-Theanine

200 mg · Settles a busy mind at bedtime

Read the deep dive

Magnesium Glycinate

11 mg (3% DV) · A gentle nighttime companion dose

Read the deep dive

Vitamin B6

5 mg (294% DV) · Support for nighttime melatonin production

Read the deep dive

Just as deliberate: what is not here.

A formula is defined by what it leaves out as much as what it puts in.

In every ritual

KSM-66 Ashwagandha, the standardized root extract
Clinically studied botanicals at honest doses
Magnesium glycinate, the well absorbed form
A hardy probiotic strain for digestive balance
Vitamins D, B6, Folate and B12
A gentle 3mg of melatonin at night

Never in the bottle

Caffeine Stimulants Added sugar Artificial colors Preservatives GMO ingredients Habit-forming sedatives Mega-dose melatonin

Vegan capsules, non-GMO, gluten-tested, made in a cGMP-certified US facility and third-party tested for purity and potency.

Now that you know what is inside.

Two formulas, one 24-hour ritual. Pick your end of the day, or cover both with the Duo.

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Third-party tested

Every batch made in a cGMP-certified US facility, tested for purity and potency.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. Reviews reflect the personal experiences of individual customers.